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TXA

Ben Addleman ben.addleman at gmail.com
Tue Apr 24 22:56:55 BST 2012


I think it's also remarkable how much weight a military study carries. Most
of my patients AREN'T young, fit men with no previous medical issues and
minimal prescription medications/alcohol/recreational drugs on board at the
time of injury.

On Tue, Apr 24, 2012 at 3:33 PM, Karim Brohi <karimbrohi at gmail.com> wrote:

> It's amazing how people won't believe a 20,000 patient RCT but will
> believe a small retrospective study.
>
> Arguably the MATTERS study has done more to improv uptake of TXA use
> in the USA than the CRASH2 study.  But of course you could read
> MATTERS as any difference between UK and US practice.  In fact, maybe
> transplanting UK surgeons to the US would improve survival??
>
> Karim
>
> On Sat, Apr 14, 2012 at 11:27, Christian Medby <cmedby at hotmail.com> wrote:
> >
> > If you don't believe in the CRASH-2 trial, check out the MATTERs study:
> >
> > TXA was found to reduce mortality from 23.9% to 17.4% and reduce
> coagulopathy in a retrospective observational military study.
> >
> > Morrison, J. J., Dubose, J. J., Rasmussen, T. E., & Midwinter, M. J.
> (2012). Military Application of Tranexamic Acid in Trauma Emergency
> Resuscitation (MATTERs) Study. Archives of Surgery, 147(2), 113–119.
> doi:10.1001/archsurg.2011.287
> >
> > Christian Medby
> > Consultant Anesthesiologist
> > Norwegian Armed Forces Medical Services
> >
> >
>


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