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Role of Steroids in Spinal Cord Inj
Karim Brohi karim at trauma.orgThu Nov 4 05:43:31 GMT 2010
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Be careful! The "Cochrane Review" was written by the same person who was lead on the NASCIS trials. I would not call this a balanced independent review. Karim On Wed, Nov 3, 2010 at 21:45, giuseppe nattino <natti56 at gmail.com> wrote: > hi all > > the last cochrane metanal. conclusions on this topic are: "High-dose > methylprednisolone steroid therapy is the only pharmacologic therapy shown > to have efficacy in a phase three randomized trial when administered within > eight hours of injury. One trial indicates additional benefit by extending > the maintenance dose from 24 to 48 hours, if start of treatment must be > delayed to between three and eight hours after injury. There is an urgent > need for more randomized trials of pharmacologic therapy for acute spinal > cord injury." > Last assessed as up-to-date: September 20. 2007 > http://www2.cochrane.org/reviews/en/ab001046.html > > this is obviously not conclusive, but the works showing no benefit (or even > harm) from the steroid use have got enough statistical strength to dissuade > everyone from using the steroid protocol? > > giuseppe > > giuseppe nattino > I servizio anestesia e rianimazione > ospedale a. manzoni > lecco - italy > -- > trauma-list : TRAUMA.ORG > To change your settings or unsubscribe visit: > http://www.trauma.org/index.php?/community/ >
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