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Role of Steroids in Spinal Cord Inj

Karim Brohi karim at trauma.org
Thu Nov 4 05:43:31 GMT 2010


Be careful!  The "Cochrane Review" was written by the same person who
was lead on the NASCIS trials.  I would not call this a balanced
independent review.
Karim

On Wed, Nov 3, 2010 at 21:45, giuseppe nattino <natti56 at gmail.com> wrote:
> hi all
>
> the last cochrane metanal. conclusions on this topic are: "High-dose
> methylprednisolone steroid therapy is the only pharmacologic therapy shown
> to have efficacy in a phase three randomized trial when administered within
> eight hours of injury. One trial indicates additional benefit by extending
> the maintenance dose from 24 to 48 hours, if start of treatment must be
> delayed to between three and eight hours after injury. There is an urgent
> need for more randomized trials of pharmacologic therapy for acute spinal
> cord injury."
> Last assessed as up-to-date: September 20. 2007
> http://www2.cochrane.org/reviews/en/ab001046.html
>
> this is obviously not conclusive, but the works showing no benefit (or even
> harm) from the steroid use have got enough statistical strength to dissuade
> everyone from using the steroid protocol?
>
> giuseppe
>
> giuseppe nattino
> I servizio anestesia e rianimazione
> ospedale a. manzoni
> lecco - italy
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