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AAST - rVIIa

KMATTOX at aol.com KMATTOX at aol.com
Tue Oct 6 12:47:59 BST 2009


 
In my view, the biggest thing to come out of the recent Amer Assoc Surgery  
of Trauma (AAST) meetings in Pittsburgh were TWO papers on analysis of 
studies  of rVIIa in real people and analyzing the past publications.   Each  
could have been labeled , "The rise and fall of rVIIa.      The studies stated 
that basically there is no advantage of any kind that can be  discovered 
from either of these two well designed studies.  One was  performed by one of 
the most respected researchers in blood, blood products,  clotting, and 
resuscitation in the world.    He stated that the  entry criteria in the cases 
from the military were so poorly controlled, that no  good statement could be 
made about just what the entry criteria should be to  design a good study 
at this point in order to study this  product.     WOW.   No different from 
the early  Israeli studies of 13 years ago.       If there  was one 
observation that I could make is that maybe the TEG could have been a  good 
instrument to determine which cases just might benefit from rVIIa to be  given.     
 
k



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