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Thu Feb 14 14:03:48 GMT 2008

So there is controversy over 1:1. How do we answer the question? Is a randomized trial justified or is it promising enough to just do it? On the one hand, we spent over 40 years using the intellectually attractive "balanced salt solution" lactated ringers without examining its impact. And blood transfusion therapy during the same interval may have been dictated by the technology that allowed fractionated blood banking - we abandoned whole blood. On the other hand, the results of 1:1 appear extremely promising. Pre-treatment Informed consent will be out of the question. Soooo, how about it Ken, Karim, Ron, Tim, all you trauma.org-istas.

Mike Sise
San Diego

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1:1 Blood Resuscitation, Round 2.