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Mon Jan 8 20:25:08 GMT 2007

Jago,

Go to Pub Med and type in aminophylline and asystole.  Interesting data,
keeping in mind that ROSC in no way implies successful cerebral
resuscitation.

Anecdotally (the best kind of evidence:))I have given it 3 times in 3
years, and have had temporary ROSC once (eventual re-arrest and
termination).  I do NOT routinely give this drug in an arrest.

Interestingly, the European Resuscitation Council has it in their 2005
guidelines (ref follows).  I cannot tell the indication from the
abstract, but would assume they are referring to asystole. 
Anaesthesist. 2006 Sep;55(9):958-66, 968-72, 974-9.

Aminophylline would not have a parasympathetic effect on the
cardiovascular system.  On the contrary, it is a methylxanthine and
would be expected to produce a sympathomimetic effect.

Hope this helps.

Regards,

Jeff

-----Original Message-----
From: trauma-list-bounces at trauma.org
[mailto:trauma-list-bounces at trauma.org] On Behalf Of Jago Miloguz
Sent: Monday, January 08, 2007 10:09 AM
To: Trauma &amp, Critical Care mailing list
Subject: AMINOPHYLLINE IN REFRACTORY ASYSTOLE

l apologize for not making it a trauma aspect directly,but nevertheless,
it
is not rare to have comorbidity of surgical and non-surgical conditions
in
same patient at the same time.
 so l was interested in hearing from first hands experiences if possible
on
use of aminophylline in asystole patients when adrenaline and atropine
aren't doing it.
 the thing  that makes me hesitate is the fact that aminophylline would
actually have a parasympathical effect on cardiovascular system
 they encourage usage due to its effect as a adenosine antagonist
so l would appreciate any advise and your experiences
regards, ante
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AMINOPHYLLINE IN REFRACTORY ASYSTOLE