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Sat Feb 10 00:55:32 GMT 2007

Can anyone send a pdf of this paper?

Thanks, Ian

>>> Sluk at harthosp.org 10/02/2007 1:55am >>>
FYI

 J Thromb Haemost. 2007 Feb;5(2):289-95. Epub 2006 Nov 16. 

Diagnosis of early coagulation abnormalities in trauma patients by
rotation
thrombelastography.

Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A,
Allaouchiche B,
Negrier C.

Laboratory of Haemostasis, Edouard Herriot Hospital, Hospices Civils de
Lyon and
Claude Bernard University, Lyon, France.

Background: Reagent-supported thromboelastometry with the rotation
thrombelastography (e.g. ROTEM((R))) is a whole blood assay that
evaluates the visco-elastic properties during blood clot formation and
clot lysis. A hemostatic monitor capable of rapid and accurate detection
of clinical coagulopathy within the resuscitation room could improve
management of bleeding after trauma. Objectives: The goals of this study
were to establish whether ROTEM correlated with standard coagulation
parameters to rapidly detect bleeding disorders and whether it can help
to guide transfusion. Methods: Ninety trauma patients were included in
the study. At admission, standard coagulation assays were performed and
ROTEM parameters such as clot formation time (CFT) and clot amplitude
(CA) were obtained at 15 min (CA(15)) with two activated tests (INTEM,
EXTEM) and at 10 min (CA(10)) with a test analyzing specifically the
fibrin component of coagulation (FIBTEM). Results: Trauma induced
significant modifications of coagulation as assessed by standard assays
and ROTEM. A significant correlation was found between prothrombin time
(PT) and CA(15)-EXTEM (r = 0.66, P < 0.0001), between activated partial
thromboplastin time and CFT-INTEM (r = 0.91, P < 0.0001), between
fibrinogen level and CA(10)-FIBTEM (r = 0.85, P < 0.0001), and between
platelet count and CA(15)-INTEM (r = 0.57, P < 0.0001). A cutoff value
of CA(15)-EXTEM at 32 mm and CA(10)-FIBTEM at 5 mm presented a good
sensitivity (87% and 91%) and specificity (100% and 85%) to detect a PT
> 1.5 of control value and a fibrinogen less than 1 g L(-1),
respectively. Conclusions: ROTEM is a point-of-care device that rapidly
detects systemic changes of in vivo coagulation in trauma patients, and
it might be a helpful device in guiding transfusion. 
PMID: 17109736 [PubMed - in process]

Stephen S. Luk, MD, FACS, FCCP
Assistant Professor of Surgery
Medical Director, ATOM Course
Hartford Hospital
EMS/Trauma Program
80 Seymour Street
Hartford, CT 06102-5037
(860) 545-3766
sluk at harthosp.org 

>>> "Hardcastle, Tim, Dr <tch at sun.ac.za>" <tch at sun.ac.za> 2/8/2007 5:25
AM >>>
Yoram

yes - it works. Just need the rapid-type machine and you can get a
result in 10 mins - much faster that INR / FBC

Tim
Dr T C Hardcastle
M.B.,Ch.B.(Stell); M.Med(Chir); FCS(SA)
Senior Surgeon / Senior Lecturer: Surgery (Trauma and ICU)
ATLS  instructor and DSTC Cape Town Course Director
Intern program Coordinator: Surgery
M.Med (Emergency Medicine) Executive Committee member
Clinical Head (Director): Diana Princess of Wales Trauma Unit
Division of Surgery (General) Room 4064
Department of Surgical Sciences
Tygerberg Hospital / University of Stellenbosch
PO Box 19063
Tygerberg 7505
Western Cape
South Africa
e-mail: tch at sun.ac.za 
Cell: +27824681615
Office: +27219389281 or 4911 pager 0302

-----Original Message-----
From: trauma-list-bounces at trauma.org
[mailto:trauma-list-bounces at trauma.org]On Behalf Of
YoramKl at clalit.org.il 
Sent: Thursday, February 08, 2007 11:17 AM
To: trauma-list at trauma.org 
Subject: thromboelastogram

Dear list members
Does anybody have any experience with the TEG (thromboelastogram)
during trauma related massive transfusion?
Thanks  
Yoram Klein
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