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Tue Sep 5 16:23:57 BST 2006

Pret,

Try: http://www.potamotrygon.de/fremdes/stingray%20article.htm

A serotonin based venom must be agonising, and worse if it got into the
pericardial sac (it is involved in cardiac pain according to the reference).
Add the necrosis from the enzymes and it sounds like a no win situation to
me. May he rest in peace, and pain free.

Guy Jackson
London, UK.

      Doggrell, Sheila A.

      Institution School of Biomedical Sciences, University of Queensland,
QLD 4072, Australia. s_doggrell at yahoo.com

      Title The role of 5-HT on the cardiovascular and renal systems and the
clinical potential of 5-HT modulation. [Review] [140 refs]

      Source Expert Opinion on Investigational Drugs. 12(5):805-23, 2003
May.

      Abstract The main peripheral sources of 5-hydroxytryptamine (5-HT) are
as a neurotransmitter and local hormone in the gastrointestinal tract, and
stored in circulating platelets and pulmonary neuroepithelial bodies. 5-HT
has been shown to have many possible physiological and pathophysiological
roles on the cardiovascular and renal systems. Thus, 5-HT may contribute to
valvular heart disease, coronary artery disease, pulmonary hypertension,
pulmonary embolism, pre-eclampsia, peripheral vascular disease and diabetic
nephropathy. Consequently, modulators of the 5-HT system have diverse
clinical potential. For instance, selective 5-HT subtype 3 receptor
(5-HT(3)) antagonists may have potential in the treatment of the pain
associated with myocardial infarction. MCI-9042 (sarpogrelate) or other
5-HT(2A) antagonists may have clinical potential for the treatment of
vasospastic angina, ischaemic heart disease, reperfusion injury and hindlimb
ischaemia. Several modulators of 5-HT (5-HT transporter inhibitors, 5-HT(1B)
and (2B) antagonists) may have potential alone or in combination in the
treatment of pulmonary hypertension. In hypertension, agonists at the
5-HT(7) and antagonists at the 5-HT(2B) may reduce blood pressure, and in
diabetes, sarpogrelate may protect against nephropathy.

----- Original Message ----- 
From: "Bjorn, Pret" <pbjorn at emh.org>
To: "Trauma &amp; Critical Care mailing list" <trauma-list at trauma.org>
Sent: Tuesday, September 05, 2006 3:50 PM
Subject: RE: Crocodile hunter- EXTRACTION of foreign body

Agreed, of course; but jeez, Dr. Mattox, you're asking a lot of the
victim here: if the reported pain factor is accurate, the impulse to
pull the barb out must be overwhelming -- even in someone who knows
better.  From what little I've seen of Steve Irwin (may he rest in
peace) the man operated largely on reflexes.

Then again, if there's truly venom involved, there may have been no
correct approach (pull the needle or leave the poison).  Does anyone on
the List know the nature of the toxin in these creatures?

If memory serves, autopsies are not always a matter of public record in
Australia.  It'd be interesting to know what was found.

Best of luck with the video, but to be honest, part of me is hopeful
it's been destroyed already.  Last thing we need on the newsstands, or
the internet.

Pret

-----Original Message-----
From: trauma-list-bounces at trauma.org
[mailto:trauma-list-bounces at trauma.org] On Behalf Of KMATTOX at aol.com
Sent: Tuesday, September 05, 2006 10:23 AM
To: trauma-list at trauma.org
Subject: Crocodile hunter- EXTRACTION of foreign body

I have learned that the victim was FILMED removing the foreign body from

this chest.   I have been unable to obtain a copy of this self
extraction of a
fatal chest penetration with a foreign body, but will keep  trying.

This will resurrect the discussions regarding removal of an impaled
foreign
body

k
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Crocodile hunter- EXTRACTION of foreign body