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Tue Apr 18 18:06:37 BST 2006

It's also important to note that increasing rates of pmem colitis as a direct result of anti-biotics offsetting colon bacteria balance has not been proven in all anti-biotics. From what I know, clinical trials have already found such phenomena in the more synthetic a-b families such as cephalosporins and quinolones, but the older and slightly "simpler" families such as penicillins and tetracyclines still remain relatively clean, or atleast uncited. Just my 2 cents. :-)

  -Mike F 

Ben Reynolds <aneurysm_42 at yahoo.com> wrote:
  Avi:

Actually a single dose isn't without significant
morbidity anymore even if your concern isn't about
breeding resistance (which should be a concern no
matter the length of antibiotic use). In general
we've seen a tremendous spike in resisitant C. diff
among our patients but we've recently had a wave
several surgical patients at my institution develop
resistant C. diff colitis after a SINGLE dose of
Ancef. One neurosurgical spine patient went on to
become toxic and required a total colectomy. 

Ben Reynolds, PA-C
Pittsburgh, PA

--- Avi Roy Shapira wrote:

> 
> K.
> 
> I don't think he is kidding. 
> 
> Single dose of pre-operative prophylactic
> antibiotics do not induce
> resistance. It is the prolonged usage of broad
> spectrum antibiotics
> that is the main cause of resistence.
> 
> The reason is the Red Queen Race Principle of
> evolutionary theory. If you
> give long courses of broad spectrum antibiotics, you
> provide a niche for
> the resitent bugs to thrive.
> 
> But if you give only a single dose of antibiotics,
> the resistant bugs
> spend too many resources for maintaining resistence,
> and therefore, in
> antibiotic free environment, cannot compete with the
> non-resistent bugs,
> like the symbiotic ones we harbour.
> 
> For a very good explanation look up a Scientific
> American article on
> antibiotic resistance (March 1998 issue)
> 
> Avi 
> 
> 
> On Thu, 13 Apr 2006 KMATTOX at aol.com wrote:
> 
> > 
> > In a message dated 4/13/2006 8:07:17 P.M. Central
> Standard Time, 
> > docrickfry at aol.com writes:
> > 
> > 
> > I'm not aware of any data that would suggest
> potential microbes are 
> > developing 
> > mass immunities as a result of prophylactic doses
> of ABs
> > 
> > 
> > You have got to be kidding or in the least
> attempting to bait others on this 
> > web site. Surely, you cannot be this naive or 
> uninformed. 
> > 
> > k
> > --
> > trauma-list : TRAUMA.ORG
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> > 
> 
>
==========================================================================
> Aviel Roy-Shapira, M.D. Soroka
> University Hospital &
> Dept. of Surgery A. and Ben-Gurion
> University Medical School 
> the Critical Care Unit POB 151, Beer
> Sheva, Israel
> 
> email:avir at bgumail.bgu.ac.il 
> Fax:972-7-6403260 voice:972-7-6403390
> 
> 
> 
> --
> trauma-list : TRAUMA.ORG
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> 

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