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The intensive care unit must act aggressive
to reverse the metabolic failure. The patient must be actively
warmed, with blankets, air-warming devices or even continuous
arteriovenous warming techniques. This is vital to allow correction
of coagulopathy and acidosis.
Acidosis is a reflection of impaired oxygen
delivery and utilization. Perfusion must be restored to body tissues
by warmed intravenous crystalloid and blood administration as
necessary. Massive tissue and bowel oedema may ensue due to the
activation and release of inflammatory mediators and large volumes
of fluid are required. Right heart catheters should be employed
as necessary to monitor cardiac filling pressures and determine
oxygen delivery. Vasodilating agents such as dobutamine or the
phsophodiesterase inhibitors may be necessary to help open up
vascular beds. In the absence of technology that can monitor muscle
and gut perfusion, the base deficit or lactate levels should be
used to guide resuscitation.
Coagulopathy is treated by the administration of fresh frozen
plasma, cryoprecipitate and platelets as necessary, and correcting
the hypothermia and acidosis. If correction of metabolic failure
is to succeed, all three derangements must be treated simultaneously
and aggressively. Take care not to miss the patient who has started
to actively bleed again. Large losses from thoracostomy tubes,
abdominal distention or loss of control of an open abdomen, or
repeated episodes of hypotension all suggest that mechanical bleeding
is occurring that will require surgical control.
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